S1667 Exploring Comorbidities in Patients With Inflammatory Bowel Disease and Coexisting Irritable Bowel Syndrome: A National Inpatient Database Study

Introduction: Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are 2 common chronic gastrointestinal disorders which can coexist in certain patients. Comorbidities have been identified in patients with IBD but little is known about comorbidities in patients with IBD and coexisting IBS. This study aims to compare comorbidities in patients with IBD and coexisting IBS (IBDIBS) vs those without coexisting IBS (IBDnoIBS). Methods: A retrospective analysis of patients admitted with a diagnosis of IBD was conducted using the National Inpatient Sample (NIS) 2020. International Classification of Diseases-10 codes were used to identify individuals with IBD which was further divided into 2 groups based on the presence or absence of a history of IBS. The risks of cardiovascular and metabolic comorbidities were compared between the 2 groups. Results: There were 308,690 patients admitted with IBD and 275 (0.09%) had coexisting IBS. There were more females in the IBDIBS group compared to the IBDnoIBS group (76.3% vs 55.3%). Mean age of presentation is relatively the same in the IBDIBS vs IBDnoIBS (50.9 vs 53.7) respectively. Majority of the population were non-Hispanic whites in IBDIBS (81.4%) and IBDnoIBS (78.0%). After adjusting for confounders, the IBDIBS group experienced a statistically significant increase in the length of hospital stay by 1.7 days (P = 0.048, 95% CI 0.17–3.49). Total hospital charges were $59,719 for IBDIBS patients compared to $67,359 for the IBDnoIBS group, with no significant difference observed after adjusting for confounders (P > 0.05). Comparing both groups, there was a significant increase in the odds of dyslipidemia (aOR 2.66, 95% CI 1.38–5.10, P = 0.03) and hypothyroidism (aOR 6.75, 95% CI 1.55–29.3, P = 0.01) in the IBDIBS group. While the odds of hypertension, obesity, coronary artery disease, and heart failure were higher in the IBDIBS group compared to the IBDnoIBS group, these findings were not statistically significant (P > 0.05). Conclusion: This study showed hospitalized patients with coexisting IBD and IBS were more likely to be women, have longer hospital stays than IBS alone. They also had higher likelihood of having dyslipidemia and hypothyroidism. These findings highlight the added clinical burden associated with coexisting IBS in patients with IBD.