Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma
Longitudinal profiling of multiple myeloma and the IME revealed dynamic immune-tumor interactions across the disease course. Altered expression in CD8+ T cells limited memory phenotype after transplant, whereas naïve B-cell recovery associated with sustained treatment response. At progression, CTAg expression associated with immunosuppression, revealing novel mechanisms of immune dysregulation.
Authors
- Hearn Jay Cho (ORCID: https://orcid.org/0000-0003-4481-5757)
- William Pilcher (ORCID: https://orcid.org/0000-0002-8544-4967)
- Reyka G. Jayasinghe (ORCID: https://orcid.org/0000-0003-2368-4890)
- Dimitra Karagkouni (ORCID: https://orcid.org/0009-0007-3961-3399)
- Ajay K. Nooka (ORCID: https://orcid.org/0000-0003-4165-6869)
- Sagar Lonial (ORCID: https://orcid.org/0000-0002-8322-9323)
- Manoj Bhasin (ORCID: https://orcid.org/0000-0001-5172-420X)
- Ravi Vij (ORCID: https://orcid.org/0000-0001-8795-3610)
- Shaji Kunnathu Kumar (ORCID: https://orcid.org/0000-0001-5392-9284)
- Chaitanya R. Acharya (ORCID: https://orcid.org/0000-0001-7149-1749)
- Edgar Gonzalez‐Kozlova (ORCID: https://orcid.org/0000-0002-6948-0626)
- George Mulligan (ORCID: https://orcid.org/0009-0009-5084-9604)
- Linda Banovic Baughn (ORCID: https://orcid.org/0000-0001-5229-4897)
- Shivani Nanda (ORCID: https://orcid.org/0000-0001-6358-2392)
- Denis Ohlstrom (ORCID: https://orcid.org/0000-0003-1920-6319)
- Yizhe Song (ORCID: https://orcid.org/0000-0001-8760-6432)
- Hope Mumme (ORCID: https://orcid.org/0000-0002-4171-1736)
- Mehmet Samur (ORCID: https://orcid.org/0000-0002-9978-5682)
- Ioannis S. Vlachos (ORCID: https://orcid.org/0000-0002-8849-808X)
- Daniel W. Sherbenou (ORCID: https://orcid.org/0000-0003-3013-7174)
- Alexander M. Gout (ORCID: https://orcid.org/0000-0001-8943-5155)
- David Avigan (ORCID: https://orcid.org/0000-0003-4624-6017)
- Junia Vieira Dos Santos (ORCID: https://orcid.org/0009-0006-9281-5937)
- Marina E. Michaud (ORCID: https://orcid.org/0000-0003-0145-7320)
- Jessica Schulman (ORCID: https://orcid.org/0000-0002-0131-3485)
- Sarthak Satpathy (ORCID: https://orcid.org/0000-0002-8275-5989)
- Steven M. Foltz (ORCID: https://orcid.org/0000-0002-9526-8194)
- Taxiarchis Kourelis (ORCID: https://orcid.org/0000-0001-8573-9434)
- Sacha Gnjatic (ORCID: https://orcid.org/0000-0001-5643-9520)
- Jonathan J. Keats (ORCID: https://orcid.org/0000-0003-4375-7399)
- Madhav V. Dhodapkar (ORCID: https://orcid.org/0000-0002-8249-5988)
- Katherine Ferguson (ORCID: https://orcid.org/0009-0000-0988-2378)
- Alessandro Laganà (ORCID: https://orcid.org/0000-0003-1134-0564)
- Nick Pabustan (ORCID: https://orcid.org/0009-0001-1996-3048)
- Li Ding (ORCID: https://orcid.org/0000-0003-1517-2975)
- Sowmitri Karthikeya Mantrala (ORCID: https://orcid.org/0000-0003-2276-7520)
Institutions
- Broad Institute (US)
- Translational Genomics Research Institute (US)
- Georgia Institute of Technology (US)
- Beth Israel Deaconess Medical Center (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Emory Healthcare (US)
- Mayo Clinic (US)
- Harvard University (US)
- Emory University (US)
- Washington University in St. Louis (US)
- Multiple Myeloma Research Foundation (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Fred Hutch Cancer Center (US)
- Harvard Affiliated Emergency Medicine Residency (US)
- Emory Clinic (US)
- Piedmont Cancer Institute (US)
- Cancer Research And Biostatistics (US)
- Dana-Farber Cancer Institute (US)
- Mayo Clinic in Arizona (US)
- Tisch Hospital (US)
- Mayo Clinic in Florida (US)
- Children's Healthcare of Atlanta (US)
- Winship Cancer Institute
- University of Colorado Anschutz Medical Campus (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1158/2643-3230.bcd-25-0205
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Multiple Myeloma Research Foundation
- Bristol-Myers Squibb
- Pfizer
- Sanofi
- Celgene
- Kowa Company
- National Institutes of Health
- Genentech
- Harvard Stem Cell Institute
- Chugai Pharmaceutical
- Kite Pharma
- Pharmacyclics
- National Heart, Lung, and Blood Institute
- National Cancer Institute
- National Institute of Diabetes and Digestive and Kidney Diseases