Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma

Longitudinal profiling of multiple myeloma and the IME revealed dynamic immune-tumor interactions across the disease course. Altered expression in CD8+ T cells limited memory phenotype after transplant, whereas naïve B-cell recovery associated with sustained treatment response. At progression, CTAg expression associated with immunosuppression, revealing novel mechanisms of immune dysregulation.

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Publication Details

Journal
Blood Cancer Discovery
Published
2025-12-09
DOI
https://doi.org/10.1158/2643-3230.bcd-25-0205
Primary Topic
Multiple Myeloma Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma

Hearn Jay Cho, William Pilcher, Reyka G. Jayasinghe, Dimitra Karagkouni et al.
Blood Cancer Discovery
Multiple Myeloma Research and Treatments
article

Longitudinal Profiling of Tumor and Immune Compartments Uncovers Patterns of Dysregulation and Associations with Response in Multiple Myeloma

Hearn Jay Cho, William Pilcher, Reyka G. Jayasinghe, Dimitra Karagkouni, Ajay K. Nooka, Sagar Lonial, Manoj Bhasin, Ravi Vij, Shaji Kunnathu Kumar, Chaitanya R. Acharya, Edgar Gonzalez‐Kozlova, George Mulligan, Linda Banovic Baughn, Shivani Nanda, Denis Ohlstrom, Yizhe Song, Hope Mumme, Mehmet Samur, Ioannis S. Vlachos, Daniel W. Sherbenou, Alexander M. Gout, David Avigan, Junia Vieira Dos Santos, Marina E. Michaud, Jessica Schulman, Sarthak Satpathy, Steven M. Foltz, Taxiarchis Kourelis, Sacha Gnjatic, Jonathan J. Keats, Madhav V. Dhodapkar, Katherine Ferguson, Alessandro Laganà, Nick Pabustan, Li Ding, Sowmitri Karthikeya Mantrala
article en

Abstract

Longitudinal profiling of multiple myeloma and the IME revealed dynamic immune-tumor interactions across the disease course. Altered expression in CD8+ T cells limited memory phenotype after transplant, whereas naïve B-cell recovery associated with sustained treatment response. At progression, CTAg expression associated with immunosuppression, revealing novel mechanisms of immune dysregulation.

Blood Cancer DiscoveryVol. 7(2)
Broad Institute (US), Translational Genomics Research Institute (US), Georgia Institute of Technology (US), Beth Israel Deaconess Medical Center (US), Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA), Emory Healthcare (US), Mayo Clinic (US), Harvard University (US), Emory University (US), Washington University in St. Louis (US), Multiple Myeloma Research Foundation (US), The Wallace H. Coulter Department of Biomedical Engineering (US), Fred Hutch Cancer Center (US), Harvard Affiliated Emergency Medicine Residency (US), Emory Clinic (US), Piedmont Cancer Institute (US), Cancer Research And Biostatistics (US), Dana-Farber Cancer Institute (US), Mayo Clinic in Arizona (US), Tisch Hospital (US), Mayo Clinic in Florida (US), Children's Healthcare of Atlanta (US), Winship Cancer Institute, University of Colorado Anschutz Medical Campus (US), Icahn School of Medicine at Mount Sinai (US)
Multiple Myeloma Research Foundation, Bristol-Myers Squibb, Pfizer, Sanofi, Celgene, Kowa Company, National Institutes of Health, Genentech, Harvard Stem Cell Institute, Chugai Pharmaceutical, Kite Pharma, Pharmacyclics, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases
Openalex Percentile: Top 41%
Multiple Myeloma Research and Treatments
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