Macropinocytosis and Vascularization Determine Response to mTOR Inhibitors in Lung Squamous Cell Carcinoma
Macropinocytosis and angiogenesis are adaptive mechanisms that support nutrient uptake and availability to drive resistance to metabolic therapies, providing a promising future therapeutic strategy to overcome metabolic flexibility of lung cancer.
Authors
- Heather R. Christofk (ORCID: https://orcid.org/0000-0002-8662-4425)
- Edward B. Garon (ORCID: https://orcid.org/0000-0001-7077-8801)
- Nedas Matulionis (ORCID: https://orcid.org/0000-0001-7624-3090)
- Morgan R. Brady (ORCID: https://orcid.org/0009-0007-1029-5745)
- David B. Shackelford (ORCID: https://orcid.org/0000-0002-8270-898X)
- Aaron Elliott Lisberg (ORCID: https://orcid.org/0000-0003-3048-4352)
- Milica Momcilovic (ORCID: https://orcid.org/0009-0004-4196-0371)
Institutions
- University of California, Los Angeles (US)
- University of Santa Monica (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0921
- Primary Topic
- PI3K/AKT/mTOR signaling in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00