Phillyrin Ameliorates Traumatic Spinal Cord Injury by Inhibiting Inflammation, Oxidative Stress, and Pyroptosis Through Modulation of the Nrf2/HO-1 Signaling Pathway
Phi alleviates SCI by activating the Nrf2/HO-1 pathway, suppressing microglial activation-mediated neuroinflammation, neuronal apoptosis, oxidative stress and pyroptosis. This study provides the first evidence of the therapeutic effect of phi on traumatic SCI, providing theoretical support for its future clinical application in SCI.
Authors
- Yang Gao (ORCID: https://orcid.org/0000-0001-9270-6251)
- K.K. Fu (ORCID: https://orcid.org/0009-0006-4907-6606)
- Yanyan Wang (ORCID: https://orcid.org/0000-0002-9888-9850)
- Li Bai (ORCID: https://orcid.org/0000-0002-0331-4342)
Institutions
- Hebei Medical University (CN)
- Third Hospital of Hebei Medical University (CN)
- Hospital of Hebei Province (CN)
- The Eighth Hospital of Xi'an (CN)
- Hebei Normal University (CN)
Publication Details
- Journal
- Immunological Investigations
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1080/08820139.2025.2599833
- Primary Topic
- Spinal Cord Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00