[ <sup>68</sup> Ga]Ga-FAPI Versus [ <sup>18</sup> F]FDG PET/CT in Signet Ring Cell Carcinoma with Linitis Plastica: Diagnostic Performance and Pitfalls
The diagnosis and staging of primary gastric carcinoma, particularly linitis plastica morphology, is challenging. Fibroblast activation protein, abundantly expressed in cancer-associated fibroblasts and absent in normal gastrointestinal mucosa, enables high tumor-to-background contrast. We report 2 cases of signet ring cell gastric adenocarcinoma with linitis plastica morphology, demonstrating minimal uptake on [<sup>18</sup>F]FDG PET/CT but intense uptake on [<sup>68</sup>Ga]Ga-FAPI-04 PET/CT. These findings highlight the superior diagnostic performance of fibroblast activation protein inhibitor imaging in this challenging subset of gastric cancers.
Authors
- Sandip Kanti Basu (ORCID: https://orcid.org/0000-0001-6607-2558)
- Keerti Sitani (ORCID: https://orcid.org/0000-0002-2374-8500)
- R.A. Agrawal
Institutions
- Bhabha Atomic Research Centre (IN)
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
Publication Details
- Journal
- Journal of Nuclear Medicine Technology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.2967/jnmt.125.270967
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00