Unlocking the benefits of aerobic exercise for MAFLD: a comprehensive mechanistic analysis
Aerobic exercise alleviates MAFLD progression by orchestrating a complex regulatory network involving energy metabolism, stress response, post-transcriptional modification, and inter-organ crosstalk. This review clarifies the key molecular targets and signaling pathways underlying aerobic exercise's therapeutic effects, providing a theoretical basis for exploring potential targeted interventions and guiding future drug development for MAFLD.
Authors
- Meixiu Jiang (ORCID: https://orcid.org/0000-0001-8747-6877)
- Bin Zhang (ORCID: https://orcid.org/0000-0003-3172-8056)
- Yu Hu
- Fang Zou (ORCID: https://orcid.org/0009-0004-2105-1939)
- Lianlei Ding
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Second Affiliated Hospital of Nanchang University (CN)
- Jiang Xi Institute for Drug Control (CN)
- Jiangxi Normal University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12967-025-07535-7
- Citations
- 2
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.33