Prognostic Value of the Albumin Corrected Anion Gap in ICU Patients with Chronic Obstructive Pulmonary Disease and Sepsis: A MIMIC-IV Cohort Study
Elevated ACAG was an independent predictor of 28-day and 365-day all-cause mortality in critically ill patients with COPD and sepsis. An inflection point of approximately 19.25 mmol/L identified a clinically meaningful threshold for risk stratification. As a simple and widely accessible parameter, ACAG may facilitate threshold-based triage and individualized management in this high-risk population, though external validation in multicenter prospective cohorts is warranted.
Authors
- Baiquan Zhang
- Lu Zhou (ORCID: https://orcid.org/0000-0002-9078-5651)
- Jing Wang (ORCID: https://orcid.org/0000-0003-3195-175X)
- Lijun Miao (ORCID: https://orcid.org/0000-0002-7778-6908)
- Jun Bai (ORCID: https://orcid.org/0000-0001-6784-4302)
- Huanqin Wang (ORCID: https://orcid.org/0000-0001-8531-5279)
- Fugui Huang (ORCID: https://orcid.org/0009-0001-7325-1447)
Institutions
- Dalian Medical University (CN)
- First Affiliated Hospital of Dalian Medical University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- International Journal of COPD
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/copd.s544857
- Citations
- 1
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 1.43
Funders
- National Natural Science Foundation of China