Evaluation of antimicrobial and antibiofilm efficacy of different antimicrobial peptides on multispecies biofilm of endodontic pathogens

DJK-5, gramicidin S, and D-Ctl peptides demonstrated remarkable efficacy against multispecies oral biofilms of <i>S. mutans</i>, <i>L. salivarius</i>, <i>A. naeslundii</i>, and <i>E. faecalis</i>. Saline showed least antimicrobial and antibiofilm activity. Sodium hypochlorite (NaOCl) showed strongest difference when compared to peptides or saline, validating it as a potent control. Hence, these peptides can be employed as potential antibiofilm agents in endodontic treatment procedures for better outcomes.