RGD-Modified Gold Nanoparticles Loaded with SAHA Remodel the Hypoxic Inflammatory Microenvironment via Inhibiting HIF-1α-VEGF Signaling to Enhance Radiosensitivity in NSCLC
RGD-AuNPs-SAHA effectively remodeled the hypoxic tumor microenvironment, attenuated oxidative stress, and suppressed pro-tumorigenic signaling, leading to significant apoptosis and DNA damage. These findings highlight its potential as a radiosensitizer for NSCLC, offering a promising strategy to improve radiation therapy outcomes.
Authors
- Jie Liang (ORCID: https://orcid.org/0000-0002-6792-8941)
- Wenbiao Chen (ORCID: https://orcid.org/0000-0002-1028-6319)
- Junqi Lin (ORCID: https://orcid.org/0000-0003-0749-2944)
- Guanle Shen (ORCID: https://orcid.org/0000-0002-2085-6530)
- Rui Song (ORCID: https://orcid.org/0000-0003-1875-2115)
- Xinhua Wang (ORCID: https://orcid.org/0009-0009-1541-6854)
- Xiaoming Huang (ORCID: https://orcid.org/0000-0002-3126-5576)
- Ruilin Yu
Institutions
- Jinan University (CN)
- Southern University of Science and Technology (CN)
- ShenZhen People’s Hospital (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/ijn.s531731
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00