A Critical Role of DC-SIGN+ Tumor-Associated Macrophages in Colorectal Cancer Immune Evasion and Progression via BCL-3-Mediated PD-L1 Expression
The DC-SIGN/BCL-3 axis in TAMs drives PD-L1 expression and contributes to CRC immune evasion. Targeting DC-SIGN<sup>+</sup> TAMs may represent a promising therapeutic strategy to reprogram the tumor microenvironment (TME) and improve the efficacy of immunotherapy in CRC.
Authors
- Chunhua Wan (ORCID: https://orcid.org/0000-0003-2896-0989)
- Baoying Hu (ORCID: https://orcid.org/0000-0002-3166-9570)
- Wenqian Xu (ORCID: https://orcid.org/0000-0002-4815-6253)
- Jianfeng Zhang (ORCID: https://orcid.org/0000-0002-2870-1146)
- Miao Chen (ORCID: https://orcid.org/0000-0002-3122-7617)
- Xingchao Wang (ORCID: https://orcid.org/0000-0002-1281-1973)
- Fei Qian (ORCID: https://orcid.org/0000-0002-9482-8815)
- Yifan Zhao (ORCID: https://orcid.org/0009-0008-0257-9235)
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- Heze Municipal Hospital (CN)
Publication Details
- Journal
- ImmunoTargets and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/itt.s562182
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00