LncRNA NONHSAT248596.1 Promotes Osteoarthritis via miR-146a-5p/CXCR4 Axis by Inducing Chondrocyte Apoptosis and Extracellular Matrix Degradation
LncRNA NONHSAT248596.1 promotes OA via miR-146a-5p/CXCR4 axis by inducing chondrocyte apoptosis and extracellular matrix degradation. These results identify NONHSAT248596.1 as a potential therapeutic target for OA intervention and underscore the miR-146a-5p/CXCR4 axis as a critical regulatory pathway for cartilage protection.
Authors
- Yaoyu Xiang (ORCID: https://orcid.org/0000-0003-3894-9548)
- Guang Yang (ORCID: https://orcid.org/0000-0002-8430-6917)
- Tengyun Yang
- Yue Yu (ORCID: https://orcid.org/0000-0002-1954-7327)
- Zhengliang Shi (ORCID: https://orcid.org/0000-0002-9658-4906)
- Guoliang Wang (ORCID: https://orcid.org/0000-0001-8032-6147)
- En Song
- Xianguang Yang (ORCID: https://orcid.org/0000-0002-7617-2816)
- Yanlin Li (ORCID: https://orcid.org/0009-0000-7135-8972)
Institutions
- Kunming Medical University (CN)
- Qujing Normal University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s558704
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00