Circulating Outer Membrane Vesicles from Gut-Colonized Carbapenem-Resistant Enterobacterales Degrade Antibiotics and Promote Bacterial Survival
Our findings reveal a novel OMV-mediated extracellular resistance mechanism that operates independently of genetic transfer, promoting bacterial persistence in the bloodstream. This study provides key insights into the role of OMVs in clinical treatment failure and identifies potential therapeutic targets to combat antibiotic resistance dissemination.
Authors
- Peifen Li
- Xihuan Sun
- Xu Yang (ORCID: https://orcid.org/0000-0001-8377-077X)
- Jiaming Huang (ORCID: https://orcid.org/0000-0001-5728-2561)
- Yingying Lin (ORCID: https://orcid.org/0009-0008-7341-8260)
- Donghong Huang
Institutions
- Fujian Medical University (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/idr.s557028
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00