Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Multicenter Cohort Study
A 30-unit increase in GGT over time was associated with a substantially higher risk of developing type 2 diabetes in children with MASLD. Together with AST, GGT may provide clinicians with concrete, routinely available parameters to monitor for early risk stratification. Further validation in independent cohorts is needed to confirm these findings and inform clinical application.
Authors
- Noé C. Crespo (ORCID: https://orcid.org/0000-0002-2302-5257)
- Lauren F. Chun
- Stavra A. Xanthakos (ORCID: https://orcid.org/0000-0001-9179-005X)
- Kimberly P. Newton (ORCID: https://orcid.org/0009-0000-9533-8685)
- Cynthia Behling
- Laura Wilson (ORCID: https://orcid.org/0000-0002-6294-4504)
- Gretchen Bandoli (ORCID: https://orcid.org/0000-0003-2167-8921)
- Rany M. Salem (ORCID: https://orcid.org/0000-0001-8816-6862)
- Jeffrey B. Schwimmer (ORCID: https://orcid.org/0000-0001-8538-2877)
- Nhat Quang N. Thai (ORCID: https://orcid.org/0009-0004-6999-3714)
- John E. Alcaraz
Institutions
- Johns Hopkins University (US)
- San Diego State University (US)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Human Longevity (United States) (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-12-09
- DOI
- https://doi.org/10.2337/dc25-1532
- Citations
- 1
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.35