A possible treatment for fragility fractures of the pelvis? The impact of probiotic treatment on pelvic bone microstructure and strength in osteoporotic rats

Probiotic treatment was shown to improve bone microstructure in osteoporotic rats, however, efficacy was related to treatment timing and duration. Administration of probiotics for 12-weeks beginning 6-weeks pre-fracture significantly enhanced bone quality in both the healing fractured and intact contralateral hemi-pelvises. This suggests a critical timing threshold exists for probiotic therapy to impact the gut microbiome, facilitating an alteration of the immune response post-fracture and producing positive structural changes in osteoporotic pelvic bone.