S1582 Gastrointestinal Cancer in Individuals With Inflammatory Bowel Disease: A Nationwide Study

Introduction: Patients with inflammatory bowel disease (IBD) face an increased risk of cancer-related mortality, encompassing both colorectal and other gastrointestinal malignancies; however, population-level data remain limited. Methods: We analyzed death certificate data from the National Center for Health Statistics (2011–2020) to assess gastrointestinal cancer-related mortality among adults with IBD, calculating age-adjusted mortality rates (AAMRs) per 100,000 population and annual percent change (APC). Results: In 2020, a total of 4,261 individuals with IBD in the United States died from gastrointestinal cancer-related causes. Between 2011 and 2020, the AAMR for gastrointestinal cancer among IBD patients showed a significant upward trend, with an APC of 2.58% (95% CI: 0.34 to 4.87%). Males consistently exhibited higher AAMRs than females, and the rate of increase was more pronounced in males (APC: 2.15%, 95% CI: 0.38 to 3.96%), whereas rates among females remained stable. Among racial and ethnic groups, non-Hispanic Black individuals experienced the greatest rise in AAMR (APC: 4.16%, 95% CI: 1.28 to 7.13%). Regionally, the Northeast showed the highest increase in gastrointestinal cancer-related AAMR (APC: 2.24%, 95% CI: 0.74 to 3.75%). Conclusion: Gastrointestinal cancer-related mortality has increased among patients with IBD, with disproportionately higher rises observed in males, non-Hispanic Black individuals, and those residing in the Northeast census region.