Pro-apoptotic effects of metformin and cisplatin in non-small cell Lung Cancer: Modulation of apoptosis-related genes and LncRNAs
The combination of cisplatin and metformin (Glucophage) exerts an additive cytotoxic effect and induces apoptosis in NSCLC cells in vitro. This effect is associated with a favorable modulation of key apoptosis-regulating genes and lncRNAs. These findings provide a strong rationale for further mechanistic and preclinical investigation of this combination therapy for lung cancer.
Authors
- Erkut Attar (ORCID: https://orcid.org/0000-0002-8459-2538)
- Niloufar Sadeghi (ORCID: https://orcid.org/0000-0001-7512-9595)
- S. Alireza Etesami (ORCID: https://orcid.org/0000-0002-7560-5464)
- Fatemeh Soleimanifar (ORCID: https://orcid.org/0000-0002-1215-1143)
- Hoda Kashani (ORCID: https://orcid.org/0009-0008-3395-654X)
- Romina Ghayoumi
Institutions
- Kashan University of Medical Sciences (IR)
- Jahrom University of Medical Sciences (IR)
- Zahedan University of Medical Sciences (IR)
- Alborz University of Medical Sciences (IR)
Publication Details
- Journal
- Cancer Treatment and Research Communications
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1016/j.ctarc.2025.101069
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81