Assessing Drug-mediated Inhibition of Liver Transporter Function with MRI: A First-in-Human Study
The biliary excretion rate and hepatocellular uptake rate of gadoxetate are promising biomarkers for research into drug-mediated inhibition of hepatocellular transporter function.
Authors
- T. J. Min
- Geoff J.M. Parker (ORCID: https://orcid.org/0000-0003-2934-2234)
- Daniel Scotcher
- Eve Shalom (ORCID: https://orcid.org/0000-0001-8762-3726)
- Nicola Melillo (ORCID: https://orcid.org/0000-0002-5229-5416)
- Ian Rowe (ORCID: https://orcid.org/0000-0003-1288-0749)
- Marta Tibiletti (ORCID: https://orcid.org/0009-0002-6857-621X)
- Ebony R. Gunwhy (ORCID: https://orcid.org/0000-0002-5608-9812)
- J. Gerry Kenna (ORCID: https://orcid.org/0000-0002-6927-8962)
- Aleksandra Galetin (ORCID: https://orcid.org/0000-0002-3933-5217)
- Paul Hockings (ORCID: https://orcid.org/0000-0002-7154-9047)
- Gunnar Schuetz
- John C. Waterton (ORCID: https://orcid.org/0000-0002-7734-2290)
- Steven Sourbron (ORCID: https://orcid.org/0000-0002-3374-3973)
Institutions
- University of Leeds (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Antaros Medical (Sweden) (SE)
- The London College (GB)
- Absynth Biologics (United Kingdom) (GB)
- University College London (GB)
- Chalmers University of Technology (SE)
- Bayer (Germany) (DE)
- University of Sheffield (GB)
Publication Details
- Journal
- Radiology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1148/radiol.251899
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00