Clinical Translation of a Dual Integrin-and GRPR-targeting PET Radiotracer 68Ga-DOTA-RGD-RM26 in Glioma
68 Ga-DOTA-RGD-RM26 exhibits superior tumor uptake and retention compared with single-targeting tracers, making it a promising tracer for the diagnosis and staging of gliomas and other brain tumors with integrin α V β 3 and GRPR expression.
Authors
- Jiarou Wang
- Zhenni Wei
- Loren Skudder‐Hill (ORCID: https://orcid.org/0000-0003-1182-3873)
- Jia Wang (ORCID: https://orcid.org/0000-0002-3110-3892)
- Peng‐Fei Xu (ORCID: https://orcid.org/0000-0003-3073-9108)
- Jingjing Zhang (ORCID: https://orcid.org/0000-0002-6948-1813)
- Ziyang Li (ORCID: https://orcid.org/0009-0002-2461-5766)
- Deling Li (ORCID: https://orcid.org/0000-0002-4300-7136)
- Xuejun Wen
- Liao Wang (ORCID: https://orcid.org/0000-0001-6573-7677)
- Zhaohui Zhu (ORCID: https://orcid.org/0000-0001-9931-850X)
- Rongxi Wang (ORCID: https://orcid.org/0000-0002-2448-2441)
- Pek‐Lan Khong (ORCID: https://orcid.org/0000-0002-9280-6778)
Institutions
- Weifang Medical University (CN)
- National University of Singapore (SG)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Institute of Neurosurgery (CN)
- Beijing Fengtai Hospital (CN)
Publication Details
- Journal
- Clinical Nuclear Medicine
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1097/rlu.0000000000006195
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00