S1327 Mortality Trends in Acute Vascular Disease of the Intestine Among US Adults: A CDC Analysis (1999-2020)

Introduction: Acute vascular disease of the intestine is a common and serious medical emergency among adults in the United States. This study investigates mortality trends and variations associated with this condition from 1999 to 2020. Methods: Mortality data from the CDC WONDER database (1999–2020) were used for retrospective analysis. Age-adjusted mortality rates (AAMRs) per 100,000 people were calculated, and trends were assessed using Average Annual Percent Change (AAPC) and Annual Percent Change (APC). Data were stratified by age, sex, race/ethnicity, and geographic region. Results: From 1999 to 2020, 46,607 deaths in the U.S. were attributed to acute vascular disease of the intestine, with most occurring in medical facilities (88.6%). The overall AAMR declined from 2.24 in 1999 to 0.48 in 2020, with an APC of -6.8756* (95% CI: -7.1519 to -6.5032). Women had higher overall AAMRs than men (1.09 vs 0.85). Mortality declined in both sexes, more notably among women (APC: -12.9200* [1999–2001], -7.3650* [2001–2013], -6.2508* [2013–2020]) than men (APC: -8.8444* [1999–2005], -6.3328* [2005–2018], followed by an increase from 2018–2020). Racial disparities were evident: Non-Hispanic Black individuals had the highest AAMR in 1999 (2.45), followed by Non-Hispanic White (2.28) and Hispanic (1.77) populations. All racial groups showed declines, with Non-Hispanic Black individuals having an AAPC of -6.9840*. Geographically, Wyoming had the highest AAMR (1.46), Hawaii the lowest (0.63). Nonmetropolitan areas had higher overall AAMRs (1.27) than metropolitan areas (0.92). Both saw declines: nonmetropolitan AAMRs fell from 2.58 in 1999 to 1.97 in 2001 (APC –11.53*), then to 0.70 in 2018 (APC –0.69*), with a slight increase thereafter. Metropolitan areas declined from 2.16 in 1999 to 1.67 in 2001 (APC –12.58*), then to 1.02 in 2012 (APC –7.53*), and further to 0.65 in 2020 (APC –5.65*). By Census region, the Midwest had the highest AAMR (1.1) and showed a marked decline from 1999 to 2014 (APC –7.20*). It was followed by the South (1), West (0.91), and Northeast (0.87). Conclusion: This study reveals substantial disparities in mortality from acute vascular disease of the intestine across demographic and geographic groups in the U.S., highlighting the need for targeted public health interventions to reduce these inequities and improve outcomes in underserved populations.