A Matched Case‐Control Study to Evaluate Predicted Drug Exposures and Neutropenia during Valganciclovir Prophylaxis in Pediatric Solid Organ Transplant Recipients
Predicted GCV exposures were similar among pSOT recipients with and without neutropenia, suggesting that differences in dosing and pharmacokinetics covariates did not drive toxicity in our population. Measurement of GCV concentrations may discern whether toxicity relates to exposures/concentrations or intrinsic factors (i.e., genetics) in the pSOT population.
Authors
- Anders Åsberg (ORCID: https://orcid.org/0000-0002-0628-1769)
- Michael Noel Neely (ORCID: https://orcid.org/0000-0002-1675-8276)
- Kevin J. Downes (ORCID: https://orcid.org/0000-0001-5015-8146)
- Mai-Uyen Nguyen (ORCID: https://orcid.org/0000-0003-0936-2019)
- Craig L K Boge (ORCID: https://orcid.org/0000-0002-9226-5529)
Institutions
- University of Southern California (US)
- Oslo University Hospital (NO)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- Thomas Jefferson University (US)
- University of Oslo (NO)
- University of Pennsylvania (US)
Publication Details
- Journal
- Transplant Infectious Disease
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1111/tid.70146
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of General Medical Sciences