Discovery of highly potent marine-derived compound Penicolinate H reveals SREBP-1 mediated lipogenesis as a druggable vulnerability in gastric cancer
Taken together, these findings highlight that SREBP-1 is an effective therapeutic target in GC and that Pen-H is a promising SREBP-1 inhibitor and a candidate for GC treatment.
Authors
- Guodi Cai (ORCID: https://orcid.org/0000-0001-9319-4091)
- Yiying Zeng (ORCID: https://orcid.org/0000-0002-9455-5239)
- Mengya Yu
- Zhenhua Zhang (ORCID: https://orcid.org/0009-0005-3908-7451)
- Fanghai Han (ORCID: https://orcid.org/0000-0001-6698-8873)
- Jing Li (ORCID: https://orcid.org/0000-0001-8669-4901)
- Hong Wang (ORCID: https://orcid.org/0000-0001-6477-7212)
- Xiaolu Wang (ORCID: https://orcid.org/0000-0001-8089-6473)
- Jun Chen (ORCID: https://orcid.org/0000-0002-8077-3403)
- Heng Cui (ORCID: https://orcid.org/0000-0003-1526-8408)
- Junjian Wang (ORCID: https://orcid.org/0000-0002-5328-2908)
- Lan Liu (ORCID: https://orcid.org/0000-0002-1425-5122)
- Jianan Tan
- Zhanfeng Gu
- Dongyue Pan
- Bin Yang (ORCID: https://orcid.org/0009-0006-7583-7712)
- Shengning Zhou
- Yana An
- Jianjiao Chen
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Jinan University (CN)
- Guangdong Pharmaceutical University (CN)
- Third Affiliated Hospital of Southern Medical University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) (CN)
- Zhejiang Provincial People's Hospital (CN)
- Guangdong Provincial People's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12967-025-07323-3
- Primary Topic
- Fatty Acid Research and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00