Association Between Iron Overload and the Risk of Ocular Hypertension, Primary Open-Angle Glaucoma, and Normal-Tension Glaucoma
Our findings suggest that patients with iron overload may benefit from targeted ophthalmologic referral, particularly those with visual symptoms or additional risk factors. The association between iron dysregulation and glaucoma highlights opportunities for interdisciplinary care, risk stratification using ferritin, and mechanistic research into ferroptosis-driven neurodegeneration, with implications for iron-targeted neuroprotective strategies.
Authors
- Chien‐Hsiang Weng (ORCID: https://orcid.org/0000-0002-0794-1263)
- Chien‐Chih Chou (ORCID: https://orcid.org/0009-0001-3470-030X)
- Ssu‐Yu Pan (ORCID: https://orcid.org/0009-0007-4620-1755)
- Jun‐Fu Lin (ORCID: https://orcid.org/0009-0006-5287-7893)
- I‐Jong Wang (ORCID: https://orcid.org/0000-0002-3045-0614)
- Shun‐Ping Huang (ORCID: https://orcid.org/0000-0002-6060-3095)
- Chang‐Youh Tsai (ORCID: https://orcid.org/0000-0002-4154-4018)
- Chieh‐Lin Jerry Teng (ORCID: https://orcid.org/0000-0001-9744-0368)
- Yi‐An Lu (ORCID: https://orcid.org/0000-0003-3532-7399)
- Wei‐Ting Ho (ORCID: https://orcid.org/0000-0001-8322-0348)
- Chen-Yu Lin (ORCID: https://orcid.org/0009-0003-7678-8199)
- Ching‐Heng Lin (ORCID: https://orcid.org/0000-0002-2450-6108)
- Ching‐Yao Tsai
- Hui-Ju Lin
Institutions
- Fu Jen Catholic University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Chung Hsing University (TW)
- Tunghai University (TW)
- National Chiayi University (TW)
- China Medical University (TW)
- University of Taipei (TW)
- Brown University (US)
- Taichung Veterans General Hospital (TW)
- Far Eastern Memorial Hospital (TW)
- Taipei City Hospital (TW)
- Ministry of Health and Welfare (TW)
- China Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Translational Vision Science & Technology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1167/tvst.14.12.13
- Primary Topic
- Iron Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taichung Veterans General Hospital