Transcatheter Mitral Valve Repair With MitraClip® in a Heart Transplant Recipient: Pushing the Limits of Percutaneous Valve Therapy

We report the case of a 62-year-old female who developed severe symptomatic functional mitral regurgitation (MR) 18 years after heart transplantation. Given her extremely high surgical risk, transcatheter edge-to-edge mitral valve repair with the MitraClip® device was selected as the most appropriate therapeutic option. The procedure was technically challenging due to altered post-transplant anatomy, but it was completed successfully without immediate complications and resulted in a substantial reduction in regurgitation. During early follow-up, a small left atrial thrombus was identified and subsequently resolved after a six-week course of oral anticoagulation. This report illustrates the feasibility and safety of transcatheter mitral repair in carefully selected heart transplant recipients and underscores the importance of tailored post-procedural surveillance in this complex population.