Rewiring central metabolism in Komagataella phaffii for efficient mannose synthesis
This study achieved efficient mannose production in K. phaffii by remodeling central metabolism. It not only offers a new route for mannose biosynthesis but also establishes a model framework for engineering K. phaffii to produce other high-value bioactive compounds.
Authors
- Xinxin Xu (ORCID: https://orcid.org/0009-0001-4049-4012)
- Yuheng Wang (ORCID: https://orcid.org/0000-0001-6394-1455)
- Sijia Zhao (ORCID: https://orcid.org/0000-0003-1309-5152)
- Wei Zhang
- Bo Liu (ORCID: https://orcid.org/0000-0003-4526-714X)
- Jiachen Xie
- Jie Zhang (ORCID: https://orcid.org/0009-0004-5173-9996)
Institutions
- Chinese Academy of Agricultural Sciences (CN)
- Biotechnology Research Institute (CA)
- Institute of Animal Sciences (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s12934-025-02886-8
- Primary Topic
- Carbohydrate Chemistry and Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00