Preliminary Evaluation of an Injectable Therapeutic for Cisplatin Ototoxicity Using Neuronal SH-SY5Y Cells
NAC is a potential therapeutic agent for cisplatin toxicity when tested in a neuronal cell line model. NAC was encapsulated into PLGA microparticles and eluted detectable concentrations of NAC for 6 days, which is a first step towards otoprotection for the weeks long duration of chemotherapy treatment. This work describes a method of screening potential therapeutics and a strategy to develop local drug eluting treatments to protect against cisplatin ototoxicity.
Authors
- Larry F. Hoffman (ORCID: https://orcid.org/0000-0003-3550-7154)
- Michelle Hong (ORCID: https://orcid.org/0000-0002-1897-8635)
- Ashley E. Kita (ORCID: https://orcid.org/0000-0002-2759-8271)
- Katherine Kedeshian (ORCID: https://orcid.org/0009-0009-3088-7283)
Institutions
- University of California, Los Angeles (US)
Publication Details
- Journal
- Medicines
- Published
- 2025-12-09
- DOI
- https://doi.org/10.3390/medicines12040030
- Primary Topic
- Hearing, Cochlea, Tinnitus, Genetics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders