Single-cell transcriptomics unveils atrazine's impact on neurons and microglia in C57BL/6 mice
Environmental ATZ exposure triggers PD-like neurodegeneration through dual mechanisms: (1) neuronal calcium dysregulation inducing oxidative stress and (2) microglia-driven neuroimmune dysfunction via CX3CL1 signaling. This study provides the novel mechanistic evidence linking ATZ to PD-like pathology via neuron-microglia crosstalk, highlighting the need for re-evaluating global ATZ exposure guidelines.
Authors
- Zhiwei Zheng (ORCID: https://orcid.org/0000-0002-8205-420X)
- Tianyu Sun (ORCID: https://orcid.org/0000-0001-9526-4591)
- Mi Pan (ORCID: https://orcid.org/0000-0002-5134-8205)
- Yongjie Ma (ORCID: https://orcid.org/0000-0002-4226-7614)
- Yan Sun (ORCID: https://orcid.org/0000-0003-1337-9454)
- Jiang Wei
- Yingjie Zhou (ORCID: https://orcid.org/0009-0008-7193-3197)
Institutions
- Guilin Medical University (CN)
Publication Details
- Journal
- Ecotoxicology and Environmental Safety
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1016/j.ecoenv.2025.119545
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00