Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Based on these results, sweet orange EO and its main component, (+)-limonene, can be considered as neuroprotective agents and are promising candidates for complementary therapy in Parkinson's disease.

Authors

Tibor Rák (ORCID: https://orcid.org/0000-0002-7652-3583)
Margita Utczás (ORCID: https://orcid.org/0000-0002-5166-7871)
Katalin Sipos (ORCID: https://orcid.org/0000-0002-6706-2682)
L. Heilmann
Györgyi Horváth (ORCID: https://orcid.org/0000-0001-5344-0294)
Adrienne Csutak (ORCID: https://orcid.org/0000-0002-7821-2412)
Edina Pandur (ORCID: https://orcid.org/0000-0001-5012-3242)

Institutions

Hungarian School Sport Federation (HU)
University of Pecs (HU)

Publication Details

Journal: BMC Complementary Medicine and Therapies
Published: 2025-12-09
DOI: https://doi.org/10.1186/s12906-025-05215-z
Primary Topic: Magnolia and Illicium research
Type: article
Field-Weighted Citation Impact: 0.00

Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Authors

Institutions

Publication Details

Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Sweet orange essential oil and (+)-limonene prevent oxidative stress, reduce inflammation, and apoptosis in differentiated SH-SY5Y neuroblastoma/BV-2 microglia co-culture neurodegeneration models

Abstract

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