Effectiveness and Tolerability of Bezafibrate in Primary Biliary Cholangitis: A Nationwide Real-World Study
In this real-world nationwide study, the one-year fibrate discontinuation rate was substantial. However off-label use of bezafibrate was associated with reductions in the biochemical markers of cholestasis in PBC, which were associated with clinical outcome in this setting of second line therapy.
Authors
- Philip W. Friederich (ORCID: https://orcid.org/0009-0004-6085-3694)
- Frans J.C. Cuperus (ORCID: https://orcid.org/0000-0001-6742-1510)
- Jan Maarten Vrolijk
- Jerome Sint Nicolaas
- Hüseyin Aktaş (ORCID: https://orcid.org/0000-0002-0580-4644)
- Robert C. Verdonk (ORCID: https://orcid.org/0000-0001-5591-0499)
- Ulrich H. Beuers (ORCID: https://orcid.org/0000-0001-5114-7799)
- Nicole S. Erler (ORCID: https://orcid.org/0000-0002-9370-6832)
- Tom J.G. Gevers (ORCID: https://orcid.org/0000-0002-3070-8443)
- Bettina E. Hansen (ORCID: https://orcid.org/0000-0001-8307-3341)
- Hajo J. Flink
- Maria C. van Hooff (ORCID: https://orcid.org/0000-0002-9383-5642)
- Sunje Abraham
- J. Marleen de Vree
- Elsemieke S. de Vries
- Harry L.A. Janssen (ORCID: https://orcid.org/0000-0003-2398-8392)
- Adriaan van der Meer (ORCID: https://orcid.org/0000-0002-9871-4022)
- Rozanne C. de Veer (ORCID: https://orcid.org/0000-0003-1604-0931)
- Merel M. Tielemans
- Cyriel Y. Ponsioen (ORCID: https://orcid.org/0000-0001-5203-0453)
- Ulrike de Wit (ORCID: https://orcid.org/0009-0006-3116-7139)
- Daphne M. Hotho
- E. Werner (ORCID: https://orcid.org/0009-0003-9410-781X)
- Ynto S. de Boer (ORCID: https://orcid.org/0000-0002-4066-7593)
- Joost P.H. Drenth (ORCID: https://orcid.org/0000-0001-8027-3073)
- Yasser A. Alderlieste (ORCID: https://orcid.org/0009-0001-7679-9280)
- Michael Klemt‐Kropp (ORCID: https://orcid.org/0000-0002-7283-371X)
- Marjo J. Kerbert-Dreteler
- Stephan Schmittgens (ORCID: https://orcid.org/0000-0002-2654-3308)
- Johan Kuijvenhoven (ORCID: https://orcid.org/0000-0002-6802-360X)
- Bart van Hoek (ORCID: https://orcid.org/0000-0001-6527-764X)
- Edith M.M. Kuiper
- Bart J. Veldt
- Suzanne van Meer (ORCID: https://orcid.org/0009-0004-8165-6753)
- Janne E. van Rooij
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Noordwest Ziekenhuisgroep (NL)
- Reinier de Graaf Hospital (NL)
- Spaarne Ziekenhuis (NL)
- Alrijne Ziekenhuis (NL)
- St. Antonius Ziekenhuis (NL)
- Amphia Ziekenhuis (NL)
- Maasstad Ziekenhuis (NL)
- Treant Zorggroep (NL)
- Ziekenhuis Nij Smellinghe (NL)
- Beatrix Kinderziekenhuis (NL)
- Isala (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Ziekenhuis Groep Twente (NL)
- Amsterdam University Medical Centers (NL)
- Rijnstate Hospital (NL)
- Meander Medisch Centrum (NL)
- 's Heeren Loo (NL)
- Bravis Ziekenhuis (NL)
- Spaarne Gasthuis (NL)
Publication Details
- Journal
- The American Journal of Gastroenterology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.14309/ajg.0000000000003879
- Citations
- 1
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 1.32