BRUIN CLL-313: Randomized Phase III Trial of Pirtobrutinib Versus Bendamustine Plus Rituximab in Untreated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Pirtobrutinib demonstrated superiority over BendaR in IRC-assessed PFS in treatment-naïve CLL/SLL. OS trends favored pirtobrutinib despite the study design allowing for crossover. Pirtobrutinib was well tolerated, consistent with its known safety profile, and more favorable than BendaR.
Authors
- Éderson Mattos
- Rodrigo Ito
- Luis Felipe Casado (ORCID: https://orcid.org/0000-0002-8171-0674)
- Tomasz Wróbel (ORCID: https://orcid.org/0000-0002-6612-3535)
- Anne Fink (ORCID: https://orcid.org/0000-0003-2106-2940)
- Michał Kwiatek (ORCID: https://orcid.org/0000-0001-9442-3124)
- Alexander Egle (ORCID: https://orcid.org/0000-0003-0648-4416)
- Katherine Bao (ORCID: https://orcid.org/0000-0001-5377-2387)
- Anna Panovská (ORCID: https://orcid.org/0000-0003-4955-3039)
- Жанет Грудева-Попова (ORCID: https://orcid.org/0000-0003-4698-8600)
- Vu Minh Hua
- Shinsuke Iida (ORCID: https://orcid.org/0000-0002-4951-960X)
- James D’Olimpio
- Weiji Su (ORCID: https://orcid.org/0000-0002-5426-9764)
- Paolo Sportoletti (ORCID: https://orcid.org/0000-0002-5630-9862)
- Jarosław Czyż (ORCID: https://orcid.org/0000-0002-4178-7837)
- Wojciech J. Jurczak (ORCID: https://orcid.org/0000-0003-1879-8084)
- Ki‐Seong Eom (ORCID: https://orcid.org/0000-0002-0578-126X)
- Alejandro Levy
- Amy S. Ruppert
- Hsuan‐Jen Shih (ORCID: https://orcid.org/0009-0000-3877-2258)
Institutions
- Eli Lilly (United States) (US)
- Masaryk University (CZ)
- University of Perugia (IT)
- Paracelsus Medical University (AT)
- Liverpool Hospital (AU)
- Medical University Plovdiv (BG)
- Nicolaus Copernicus University (PL)
- Chang Gung Memorial Hospital (TW)
- Nagoya City University (JP)
- Wroclaw Medical University (PL)
- Hospital Amaral Carvalho (BR)
- Linkou Chang Gung Memorial Hospital (TW)
- HM Hospitales (ES)
- Collegium Medicum in Bydgoszcz (PL)
- Krakow Cardiovascular Research Institute (PL)
- St. Paul's Hospital (KR)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
- Manor Hospital (GB)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1200/jco-25-02380
- Citations
- 1
- Primary Topic
- Chronic Lymphocytic Leukemia Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63