Visible-Light-Induced Trifluoromethyloximation of Alkenes with Sodium Nitrite as Oxime Source

A visible-light-induced, transition-metal- and photosensitizer-free three-component trifluoromethyloximation of alkenes is described herein. This established visible-light-driven difunctionalization process enables the straightforward and productive preparation of a diverse array of α-CF₃ ketoximes with high regioselectivity. The strategy employs commercially abundant and robust alkenes as starting materials, economical CF₃SO₂Cl as the trifluoromethylating agent, and NaNO₂ as the nitrosyl source, operating without transition-metal catalysts or external photosensitizers. This approach demonstrates broad functional group compatibility, high selectivity, mild reaction conditions, and excellent practicality.