Aluminum-[18F]fluoride radiolabeling of triarylphosphines for cell labeling via the perfluoroaryl azide Staudinger ligation
While the Al[<sup>18</sup>F]F radiolabeling of these (+)-RESCA-bearing small molecules offers high stability against demetallation and/or defluorination, the method cannot currently be applied to triarylphosphines due to oxidation during radiolabeling and requires further development. Among the synthesized compounds, the cyclohexyl-linked derivative exhibited the most favorable stability profile, making it a potential lead structure for future tracer development. Nevertheless, this study advanced our understanding of MGE with PFAA-derivatized monosaccharides and highlighted the need for further investigation before applying PFAA-Staudinger ligation to cell radiolabeling.
Authors
- Anisa Biti
- Topias Pöllänen
- Heidi Harjunpää (ORCID: https://orcid.org/0000-0002-1380-9939)
- Surachet Imlimthan (ORCID: https://orcid.org/0000-0003-2520-2146)
- Susanne Κ. Wiedmer (ORCID: https://orcid.org/0000-0002-3097-6165)
- Arina A. Sukhova (ORCID: https://orcid.org/0000-0003-1179-1189)
- Mirkka P. Sarparanta (ORCID: https://orcid.org/0000-0002-2956-4366)
- Susanna C. Fagerholm (ORCID: https://orcid.org/0000-0002-0354-8763)
- Filip S. Ekholm (ORCID: https://orcid.org/0000-0002-4461-2215)
- Diana Barakhtii
Institutions
- University of Helsinki (FI)
Publication Details
- Journal
- EJNMMI Radiopharmacy and Chemistry
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1186/s41181-025-00409-9
- Citations
- 1
- Primary Topic
- Click Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.94