A mitochondria-targeted green light-activatable binuclear ruthenium( <scp>ii</scp> ) dithiocarbamate complex for synergistic type I/II photodynamic therapy
We report the synthesis of a mitochondria-targeted binuclear ruthenium(II)-dithiocarbamate complex, [Ru(bpy)<sub>2</sub>(S<sub>2</sub>C(C<sub>4</sub>H<sub>8</sub>N<sub>2</sub>)CS<sub>2</sub>)Ru(bpy)<sub>2</sub>](PF<sub>6</sub>)<sub>2</sub> (Ru1), with a significant bathochromic absorbance shift when compared with the well-studied mononuclear [Ru(bpy)<sub>3</sub>]Cl<sub>2</sub> complex. It demonstrates excellent singlet oxygen (<sup>1</sup>O<sub>2</sub>) and hydroxyl radical (˙OH) generation ability under green (518 nm)/red (637 nm) light, even at ultra-low power intensity (10 mW cm<sup>-2</sup>). It elicits potent photocytotoxicity against human lung cancer cells (A549) <i>in vitro</i> and in a 3D tumor spheroid model <i>via</i> type I/II photodynamic therapy.
Authors
- V. Venkatesh (ORCID: https://orcid.org/0000-0001-9520-6842)
- Monika Negi (ORCID: https://orcid.org/0009-0005-4289-1440)
Institutions
- Indian Institute of Technology Roorkee (IN)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1039/d5dt01997d
- Primary Topic
- Metal complexes synthesis and properties
- Type
- article
- Field-Weighted Citation Impact
- 0.00