Cyclodextrin-based inclusion complexes to enhance the solubility and oral bioavailability of indapamide: experimental and computational approaches

The integrated findings highlight the superior potential of modified cyclodextrins, particularly sulfobutylether-β-CD, as excipients for improving solubility, dissolution, and oral bioavailability of indapamide. These results establish a mechanistic foundation for future formulation strategies targeting poorly water-soluble diuretics and related therapeutic agents.