Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease
This study shows that dextran sodium sulfate (DSS), a chemical used to model gut inflammation in mice, also causes gum disease-like changes-including bone loss, inflammation, and changes in oral bacteria. These findings reveal that DSS alone can affect the mouth and may confound studies investigating links between gum disease and inflammatory bowel disease, highlighting the need for better-controlled models.
Authors
- Jean‐Pierre Raufman (ORCID: https://orcid.org/0000-0002-6340-4382)
- Cindy Q. Zhou (ORCID: https://orcid.org/0000-0002-6411-3333)
- Himanshi Tanwar (ORCID: https://orcid.org/0009-0000-2612-0957)
- Massimo Costalonga (ORCID: https://orcid.org/0000-0001-5922-3709)
- Jeba Mercy Gnanasekaran
- Niyant Ganesh (ORCID: https://orcid.org/0009-0008-2871-1134)
- Vivek Thumbigere‐Math (ORCID: https://orcid.org/0000-0002-8279-3766)
- Hanping Feng (ORCID: https://orcid.org/0000-0002-8685-1812)
- Amy Plotkin
- Priyam Jani (ORCID: https://orcid.org/0000-0001-7768-7865)
- Fenfen Zhou
- Giacomo Baima (ORCID: https://orcid.org/0000-0002-9395-4967)
Institutions
- University of Maryland, Baltimore (US)
- University of Minnesota (US)
- University of Maryland Medical Center (US)
- Department of Medical Sciences (BY)
- VA Maryland Health Care System (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
- International University College of Turin (IT)
- University of Turin (IT)
Publication Details
- Journal
- Journal of Periodontology
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1002/jper.70045
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00