Characterizing population-wide genomic risk distribution for development of a novel clinical-genomic risk system for prognostication in patients with clinically localized prostate cancer
These findings suggest integration of genomic and clinicopathologic risk may lead to more nuanced risk assessment in prostate cancer and may help individualize treatment consideration.
Authors
- Elai Davicioni (ORCID: https://orcid.org/0000-0001-9136-099X)
- Fábio Ynoe de Moraes (ORCID: https://orcid.org/0000-0003-3407-9215)
- Todd Matthew Morgan (ORCID: https://orcid.org/0000-0002-1140-0603)
- Elizabeth C. Chase (ORCID: https://orcid.org/0000-0003-0452-2976)
- Krithika Suresh (ORCID: https://orcid.org/0000-0001-7785-3536)
- Robert Timothy Dess (ORCID: https://orcid.org/0000-0003-2331-3758)
- Stephen J. Freedland (ORCID: https://orcid.org/0000-0002-8104-6419)
- Angela Y. Jia (ORCID: https://orcid.org/0000-0002-0812-2614)
- Brian J. Davis (ORCID: https://orcid.org/0000-0002-8288-1096)
- Brad J. Stish
- William J. Aronson (ORCID: https://orcid.org/0000-0003-2107-5362)
- Curtiland Deville (ORCID: https://orcid.org/0000-0003-4846-6486)
- Ralph Jiang (ORCID: https://orcid.org/0000-0001-9940-4109)
- Matthew J. Schipper (ORCID: https://orcid.org/0000-0001-6728-4720)
- Udit Singhal (ORCID: https://orcid.org/0000-0002-3928-9476)
- Will Jackson (ORCID: https://orcid.org/0000-0001-8709-5978)
- Daniel Eidelberg Spratt (ORCID: https://orcid.org/0000-0002-5973-4741)
- Martha K. Terris (ORCID: https://orcid.org/0000-0002-3843-7270)
- Michael J. Zeléfsky (ORCID: https://orcid.org/0000-0002-6090-6424)
- Soumyajit Roy (ORCID: https://orcid.org/0000-0001-6617-5522)
- Matthew R. Cooperberg (ORCID: https://orcid.org/0000-0003-4339-6685)
- Alejandro Berlín (ORCID: https://orcid.org/0000-0002-1880-6905)
- Tudor Borza (ORCID: https://orcid.org/0000-0001-9164-6605)
- James A. Proudfoot (ORCID: https://orcid.org/0009-0008-7063-5761)
- R. Jeffrey Karnes
- Jonathan Shoag
- Nicholas G. Zaorsky
Institutions
- Cedars-Sinai Medical Center (US)
- Johns Hopkins University (US)
- University of Toronto (CA)
- Queen's University (CA)
- Augusta University (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Kingston General Hospital (CA)
- Los Angeles Medical Center (US)
- University of California San Francisco Medical Center (US)
- Michigan Medicine (US)
- University Hospitals Seidman Cancer Center (US)
- Veracyte (United States) (US)
- Mayo Clinic in Arizona (US)
- Durham VA Medical Center (US)
- New York University (US)
Publication Details
- Journal
- Prostate Cancer and Prostatic Diseases
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1038/s41391-025-01062-8
- Citations
- 1
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Prostate Cancer Foundation
- A. Alfred Taubman Medical Research Institute
- National Institutes of Health