Pharmacological Mechanisms of CheReCunJin Formula in Ameliorating Sjögren’s Syndrome: Suppression of IL-17 Signal-Mediated Inflammatory Cascade
CRCJ protected salivary glands in SS by inhibiting IL-17 signal-mediated inflammatory cascade, an effect likely attributable to key bioactive components such as luteolin 7-O-β-D-glucoside, rutin, 1,4-dicaffeoylquinic acid, and anemarrhenasaponin C. This study provides a foundation for the further development and clinical application of CRCJ for the treatment of SS.
Authors
- Fei Li (ORCID: https://orcid.org/0000-0001-9203-9815)
- Xiao Xue (ORCID: https://orcid.org/0000-0002-1822-0402)
- Shasha Li (ORCID: https://orcid.org/0000-0001-9177-8173)
- Haoran Chen (ORCID: https://orcid.org/0000-0001-6307-0637)
- Bin Wu (ORCID: https://orcid.org/0000-0003-0309-1502)
- Shikai Yan (ORCID: https://orcid.org/0000-0002-1862-225X)
- Yuanfang Sun (ORCID: https://orcid.org/0009-0000-8909-1743)
- Lijing Du
- Yu Gan (ORCID: https://orcid.org/0000-0002-8654-7597)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shanghai Jiao Tong University (CN)
- Guangdong Pharmaceutical University (CN)
- First People's Hospital of Chongqing (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jir.s544874
- Primary Topic
- Salivary Gland Disorders and Functions
- Type
- article
- Field-Weighted Citation Impact
- 0.00