Should transarterial chemoembolization be applied with systemic therapy for hepatocellular carcinoma with hepatic vein and/or inferior vena cava tumor thrombus (CHANCE2505)?: A multicenter study
TACE in combination with systemic therapy shows improved survival benefit and manageable safety profiles compared to systemic therapy alone for HCC patients with HVTT/IVCTT. These findings provide preliminary evidence supporting the integration of TACE into first-line systemic therapy for this patient population. However, given the retrospective nature of this study, validation through prospective randomized controlled trials is warranted.
Authors
- Jian-Jia Chen (ORCID: https://orcid.org/0000-0001-8114-9760)
- Yang Weizhu (ORCID: https://orcid.org/0000-0002-7712-5966)
- Guan‐Hui Zhou (ORCID: https://orcid.org/0000-0001-7856-0815)
- Ming Huang (ORCID: https://orcid.org/0009-0006-0248-408X)
- Chang Zhao
- Jiansong Ji (ORCID: https://orcid.org/0000-0002-6026-3676)
- Long-Wang Lin
- Hong-Tao Hu (ORCID: https://orcid.org/0000-0002-5432-4014)
- Zhicheng Jin (ORCID: https://orcid.org/0000-0003-2770-9549)
- Hai‐Dong Zhu (ORCID: https://orcid.org/0000-0003-1798-7641)
- Qian Chen (ORCID: https://orcid.org/0000-0002-1909-302X)
- Weidong Wang
- Aibing Xu
- Zhou-Chao Hu
- Xiaoli Zhu (ORCID: https://orcid.org/0000-0003-1723-4527)
- Hai‐Bin Shi (ORCID: https://orcid.org/0000-0003-3078-9308)
- Yun Zhou (ORCID: https://orcid.org/0000-0003-3988-3982)
- Guohui Xu
Institutions
- Fujian Medical University (CN)
- University of British Columbia (CA)
- Kunming Medical University (CN)
- Lishui University (CN)
- Zhengzhou University (CN)
- Soochow University (CN)
- Nantong Tumor Hospital (CN)
- Zhongda Hospital Southeast University (CN)
- Sichuan Cancer Hospital (CN)
- Zhoushan Hospital (CN)
- Henan Cancer Hospital (CN)
- Jiangsu Province Hospital (CN)
- First Affiliated Hospital of Soochow University (CN)
- Tumor Hospital of Guangxi Medical University (CN)
- Wuxi People's Hospital (CN)
- Union Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1097/js9.0000000000004144
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00