General vs. Regional anesthesia: differential effects on postoperative anxiety, depression, and stress biomarkers in arthroscopic knee surgery: a randomized clinical trial
GA exhibits lower postoperative anxiety in ACLR patients, whereas RA shows superior perioperative SC suppression. SC did not mediate the relationship between anesthesia technique and postoperative anxiety. These findings suggest GA may benefit anxiety-prone individuals, while RA appears advantageous for stress-sensitive cases.
Authors
- Congcong Huang (ORCID: https://orcid.org/0000-0001-5288-9540)
- Xudong Du (ORCID: https://orcid.org/0000-0001-8723-9898)
- Chunwei Lian (ORCID: https://orcid.org/0000-0003-4702-6147)
- Xiaocou Wang (ORCID: https://orcid.org/0000-0002-8156-5091)
- Yu Che
- Fang Gao Smith (ORCID: https://orcid.org/0000-0002-8095-0609)
- Jun Li (ORCID: https://orcid.org/0000-0002-0179-4151)
- Ting Li (ORCID: https://orcid.org/0000-0001-5145-3024)
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Shaoxing People's Hospital (CN)
- University of Birmingham (GB)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1097/js9.0000000000004404
- Primary Topic
- Music Therapy and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00