Efficacy and mechanism of Shugan Jieyu combined with sertraline in alcohol-dependent patients with depression: A randomized clinical study
SJC-sertraline combination therapy accelerates depressive symptom relief (by 2 weeks) and improves response rates (+16.7%) in alcohol-dependent patients, without increasing adverse events. Clinical outcomes suggest potential synergistic mechanisms, though no biomarker analyses were performed.
Authors
- Hui Xing (ORCID: https://orcid.org/0009-0005-3681-5361)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-9625-2581)
- Juan Yan
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Medical and Health Group Hangzhou Hospital (CN)
- Hangzhou Seventh Peoples Hospital (CN)
Publication Details
- Journal
- World Journal of Psychiatry
- Published
- 2025-11-25
- DOI
- https://doi.org/10.5498/wjp.v15.i12.111801
- Citations
- 1
- Primary Topic
- Alkaloids: synthesis and pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.56