MK-7602: a potent multi-stage dual-targeting antimalarial
This work was funded by The Wellcome Trust (109662/Z/15/Z, 202749/Z/16/Z, 219658/Z/19/Z), NHMRC (GNT1176955, GNT637406, GNT1173049), the Human Frontiers Science Program (LT0001/2022-L, JMD), Drakensberg Trust, the Victorian State Government Operational Infrastructure Support grant, and the Australian Government NHMRC IRIISS. JPo was supported by the NIH/NIAID (R01AI173171, R01AI175134 and R61AI187100) and the Pasteur International Unit PvESMEE.
Authors
- David B. Olsen (ORCID: https://orcid.org/0000-0001-5521-0206)
- Manuel de Lera Ruiz (ORCID: https://orcid.org/0000-0002-4355-9782)
- Zhiyu Lei (ORCID: https://orcid.org/0009-0003-1972-8990)
- John A. McCauley
- Anthony N. Hodder (ORCID: https://orcid.org/0000-0001-8328-5301)
- Nicholas Murgolo (ORCID: https://orcid.org/0000-0001-7094-3344)
- Josephine Palandri
- Lionel Brice Feufack-Donfack (ORCID: https://orcid.org/0000-0003-1578-455X)
- Alan F. Cowman (ORCID: https://orcid.org/0000-0001-5145-9004)
- Andrew Danziger
- Marissa Vavrek (ORCID: https://orcid.org/0000-0003-0240-2583)
- Ágnes Orbán (ORCID: https://orcid.org/0000-0001-5865-2106)
- Maria V. Fawaz (ORCID: https://orcid.org/0000-0002-4743-1444)
- Anthony T. Papenfuss (ORCID: https://orcid.org/0000-0002-1102-8506)
- Anna Ngo (ORCID: https://orcid.org/0000-0001-5684-6978)
- James McCarthy (ORCID: https://orcid.org/0000-0001-6596-9718)
- Rachael Coyle (ORCID: https://orcid.org/0000-0001-5838-1086)
- Justin A. Boddey (ORCID: https://orcid.org/0000-0001-7322-2040)
- Richard W. Birkinshaw (ORCID: https://orcid.org/0000-0003-1825-0182)
- Brad E. Sleebs (ORCID: https://orcid.org/0000-0001-9117-1048)
- Kitsanapong Reaksudsan
- Tony Triglia
- Ryan Steel (ORCID: https://orcid.org/0000-0002-4802-2896)
- Jean Popovici (ORCID: https://orcid.org/0000-0002-3135-1175)
- Jocelyn Sietsma Penington (ORCID: https://orcid.org/0000-0003-1561-0074)
- Kym N. Lowes (ORCID: https://orcid.org/0000-0003-3506-4218)
- Madeline G. Dans (ORCID: https://orcid.org/0000-0001-9386-0648)
- S.W. Scally (ORCID: https://orcid.org/0000-0002-4264-7772)
- Michael Kelly (ORCID: https://orcid.org/0000-0001-7955-3860)
- Jerzy M. Dziekan
- Paola Favuzza (ORCID: https://orcid.org/0000-0002-1394-927X)
- Christopher W. Boyce
- Jonathan A. Robbins (ORCID: https://orcid.org/0000-0001-9690-4976)
- Nicole Sevilleno
- Lee M (ORCID: https://orcid.org/0000-0002-4973-0915)
- Lianyun Zhao
- Zhuyan Guo
- Jennifer K. Thompson
- Wendy Bailey
Institutions
- United States Military Academy (US)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Université Paris Cité (FR)
- Wellcome Sanger Institute (GB)
- Wellcome Centre for Anti-Infectives Research (GB)
- Institut Pasteur du Cambodge (KH)
Publication Details
- Journal
- EBioMedicine
- Published
- 2025-12-06
- DOI
- https://doi.org/10.1016/j.ebiom.2025.106061
- Citations
- 1
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Wellcome Trust
- Australian Government
- National Institute of Technology Delhi
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Allergy and Infectious Diseases