Applicability and feasibility of the updated <scp>ILAE</scp> seizure classification in secondary referral centers

This prospective multicenter study aimed to evaluate the applicability and feasibility of the updated International League Against Epilepsy (ILAE) seizure classification (basic version) in secondary referral centers, using information from history-taking and basic investigations (routine or sleep electroencephalography, and computed tomography or magnetic resonance imaging when indicated). The primary outcome was the proportion of patients whose seizures could be classified. Secondary outcomes addressed the new elements introduced in the updated classification: ictal responsiveness and recall (awareness) for classifying the state of consciousness, and the basic seizure descriptors (with vs. without observable manifestations). Data from 458 consecutive patients (152 pediatric) across seven outpatient epilepsy clinics were analyzed. All seizures could be classified according to the basic version of the updated ILAE seizure classification. Information on awareness was available in 396 patients (86.5%) and on responsiveness in 380 (83.0%). In 11 patients (2.4%), the ictal state of consciousness could not be determined. Information on basic seizure descriptors was available for 452 patients (98.7%). These findings indicate that the basic version of the updated ILAE seizure classification is feasible and applicable at secondary referral centers. Moreover, state of consciousness and basic seizure descriptors can be inferred from history in nearly all patients.

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Publication Details

Journal
Epilepsia
Published
2025-12-08
DOI
https://doi.org/10.1002/epi.70050
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
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article

Applicability and feasibility of the updated ILAE seizure classification in secondary referral centers

Ioana Grigore, Sándor Beniczky, Vharoon Sharma Nunkoo, Károly Orbán-Kis et al.
Epilepsia
Epilepsy research and treatment
article

Applicability and feasibility of the updated ILAE seizure classification in secondary referral centers

Ioana Grigore, Sándor Beniczky, Vharoon Sharma Nunkoo, Károly Orbán-Kis, Krisztina Kelemen, Eugen Trinka, Bogdan Florea, Alina Georgeta Ghiață, Réka Gál Kraft, Katalin Ruff, Ilie Ciprian Rociu, Zseni Ibolya Kertész, Cristina Boghean
article en

Abstract

This prospective multicenter study aimed to evaluate the applicability and feasibility of the updated International League Against Epilepsy (ILAE) seizure classification (basic version) in secondary referral centers, using information from history-taking and basic investigations (routine or sleep electroencephalography, and computed tomography or magnetic resonance imaging when indicated). The primary outcome was the proportion of patients whose seizures could be classified. Secondary outcomes addressed the new elements introduced in the updated classification: ictal responsiveness and recall (awareness) for classifying the state of consciousness, and the basic seizure descriptors (with vs. without observable manifestations). Data from 458 consecutive patients (152 pediatric) across seven outpatient epilepsy clinics were analyzed. All seizures could be classified according to the basic version of the updated ILAE seizure classification. Information on awareness was available in 396 patients (86.5%) and on responsiveness in 380 (83.0%). In 11 patients (2.4%), the ictal state of consciousness could not be determined. Information on basic seizure descriptors was available for 452 patients (98.7%). These findings indicate that the basic version of the updated ILAE seizure classification is feasible and applicable at secondary referral centers. Moreover, state of consciousness and basic seizure descriptors can be inferred from history in nearly all patients.

EpilepsiaVol. 67(2)
University of Copenhagen (DK), Lucian Blaga University of Sibiu (RO), Technical University of Cluj-Napoca (RO), University of Oradea (RO), Paracelsus Medical University (AT), Clinical Emergency Hospital Bucharest (RO), Copenhagen University Hospital (DK), Rigshospitalet (DK), University of Saint Mary (US), Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș (RO), Agora University (RO), Austrian Institute for Health Technology Assessment GmbH (AT), Christian Doppler Klinik (AT), Bogdan Voda University (RO), County Hospital (GB), Fondation Lenval (FR), Spitalul Clinic Judetean de Urgenta Târgu Mureş (RO), Epilepsy Action (GB), Spitalul Clinic Judetean Mures (RO), Epilepsy Foundation (AU)
Openalex Percentile: Top 54%
Epilepsy research and treatment
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