LRRK2 G2019S mutation contributes to mitochondrial transfer dysfunction in a Drp1-STX17-dependent manner
The impairment of mitochondrial transfer is a potential pathogenic mechanism associated with LRRK2 G2019S mutation. The molecular mechanisms of mitochondrial transfer were observed to occur through a Drp1-STX17-dependent pathway. Notably, inhibitors for Drp1 Ser616 phosphorylation may offer neuroprotection through mitigating mitochondrial transfer impairments. This study provides novel insights into the pathogenesis of PD and the development of new therapeutic targets.
Authors
- Chao Ma (ORCID: https://orcid.org/0000-0001-8334-8659)
- Jin-Ru Zhang
- Wang Fen (ORCID: https://orcid.org/0000-0001-9451-0578)
- Juan Li (ORCID: https://orcid.org/0000-0003-4245-4679)
- Chun‐Feng Liu (ORCID: https://orcid.org/0000-0002-8364-0219)
- Xiao‐Kang Li (ORCID: https://orcid.org/0000-0002-0897-2141)
- Junyi Liu (ORCID: https://orcid.org/0000-0001-5702-3519)
- Mei Ding (ORCID: https://orcid.org/0000-0003-3920-568X)
- Jin Hong (ORCID: https://orcid.org/0000-0002-8757-2700)
- Yue Qi (ORCID: https://orcid.org/0000-0002-7699-5572)
- Lanlan Jiang (ORCID: https://orcid.org/0000-0003-3683-6419)
- Xiao-Yu Cheng
- Cheng-Jie Mao
- Meixia Wang (ORCID: https://orcid.org/0000-0003-2683-6079)
Institutions
- Nantong University (CN)
- Soochow University (CN)
- Second People's Hospital of NanTong (CN)
- Suzhou Municipal Hospital (CN)
- Beijing Xuanwu Traditional Chinese Medicine Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
- Ningxia Medical University (CN)
- National Center For Child Health and Development (JP)
- The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital)
- Second Affiliated Hospital of Nantong University
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s40035-025-00525-1
- Citations
- 1
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province