Ultrasensitive ELISA for Accurate Detection of <i>Plasmodium falciparum</i> Infection
The detection sensitivity of our system is approximately 10 times greater than that of the latest ultrasensitive antigen detection kits. Our results demonstrate that our developed assay requires no additional processing to separate parasitized erythrocytes from whole blood samples and that the <i>pfhrp2</i>-gene deletion strain can be successfully detected using the pLDH-based TN-cyclon™ test.
Authors
- Yuki Kobayashi (ORCID: https://orcid.org/0000-0001-7389-5667)
- Kiichi Okita
- Po-Kai Chen (ORCID: https://orcid.org/0009-0006-7830-0590)
- Eri Hayakawa (ORCID: https://orcid.org/0000-0001-5067-2161)
- Etsuro Ito (ORCID: https://orcid.org/0000-0002-1877-6566)
- Teruki Yoshimura (ORCID: https://orcid.org/0000-0001-5704-7123)
- Mitsumasa Hasunuma
- Taisei Tsuneki
Institutions
- Jichi Medical University (JP)
- Waseda University (JP)
- Kaohsiung Medical University (TW)
- Health Sciences University of Hokkaido (JP)
- Hokkaido Pharmaceutical University (JP)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-11-15
- DOI
- https://doi.org/10.1093/ofid/ofaf711
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00