MNX1 prevents somatostatin expression in human beta cells by repressing PERCC1
We discovered a novel MNX1-PERCC1-HHEX regulatory axis in human beta cells. In these cells, MNX1 protects beta cell identity by inhibiting PERCC1, an activator of HHEX and SST expression. PERCC1 may thus be considered as a sharply tuned central hub for somatostatin regulation. Our results increase our knowledge of beta cell plasticity, and may have implications for therapeutic strategies aimed at protecting beta cell identity.
Authors
- Raphaël Scharfmann (ORCID: https://orcid.org/0000-0001-7619-337X)
- Alexis Fouque
- Philippe Ravassard (ORCID: https://orcid.org/0000-0002-0393-9262)
- Olivier Albagli
- Farah Kobaisi (ORCID: https://orcid.org/0000-0001-9193-1588)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Institut de Biologie Paris-Seine (FR)
- Institut Cochin (FR)
- Institut du Cerveau (FR)
- Adaptation Biologique et Vieillissement (FR)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1007/s00125-025-06620-2
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- Diabetes Fonds
- Stichting Diabetes Onderzoek Nederland