KLF10-IN-1 Attenuates RPE Cell Apoptosis and Experimental Diabetic Retinopathy Via the KLF10/PERK/eIF2α/ATF4/CHOP Pathway
KLF10 is upregulated in DR model mice and high-glucose/hypoxia-exposed RPE cells and modulates apoptosis and ER stress through the PERK/eIF2α/ATF4/CHOP pathway. KLF10-IN-1 has protective effects, suggesting its potential for early DR treatment.
Authors
- Weiwen Hu (ORCID: https://orcid.org/0000-0003-3027-4574)
- Ying Tu (ORCID: https://orcid.org/0009-0008-0130-0239)
- Y Wang
- Qiong Zhou (ORCID: https://orcid.org/0000-0002-5704-494X)
- Qiqi Zhu (ORCID: https://orcid.org/0000-0001-8010-5707)
- Guanghao Zheng
- Yeting Lin
- Heng Yang (ORCID: https://orcid.org/0000-0002-5635-8533)
- Jian Tan (ORCID: https://orcid.org/0000-0002-2914-0598)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Nanchang University (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Henan Provincial People's Hospital (CN)
- Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1167/iovs.66.15.25
- Citations
- 1
- Primary Topic
- Kruppel-like factors research
- Type
- article
- Field-Weighted Citation Impact
- 0.81