Cancer-associated adipocytes promote peritoneal metastasis of colorectal signet ring cell carcinoma via FABP4 induction
CAA-derived exosomal signaling promotes SRCC aggressiveness through FABP4-mediated fatty acid metabolic reprogramming, identifying FABP4 as a potential therapeutic target for peritoneal metastasis in colorectal SRCC.
Authors
- Ruiqi Gu
- Wenqin Luo (ORCID: https://orcid.org/0000-0002-2486-807X)
- Senlin Zhao (ORCID: https://orcid.org/0000-0001-7079-0771)
- Weixing Dai (ORCID: https://orcid.org/0000-0002-5395-8568)
- Guoxiang Cai (ORCID: https://orcid.org/0000-0003-2953-3460)
- Yikuan Chen (ORCID: https://orcid.org/0000-0002-9835-8881)
- Renjie Wang
- Hong-Sheng Fang
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s12964-025-02569-2
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.00