Mild and Practical Method for the Synthesis of Sterically Hindered 5,5-Disubstituted Hydantoins with CO <sub>2</sub>
A mild and practical method was reported for the first time to prepare a variety of important sterically hindered 5,5-disubstituted hydantoins through carbonylative cyclization, which employed 1 atm of CO<sub>2</sub> as the green carbonyl source, without using transition-metal catalysts and oxidants. This efficient process features good functional group compatibility, a broad substrate scope, facile scalability, and easy product transformation. Its utility has been demonstrated by synthesizing different medicines and bioactive compounds. This method could also be well applied to construct other types of hydantoins.
Authors
- Naifu Hu (ORCID: https://orcid.org/0000-0002-2605-0562)
- Kuoqi Yang
- Lijun Yin (ORCID: https://orcid.org/0009-0002-5655-999X)
Institutions
- Institute for Advanced Study (DE)
- ZheJiang Institute For Food and Drug Control (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1021/acs.joc.5c02321
- Citations
- 1
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.70