<scp>TMEM106A</scp> as a Macrophage‐Associated Biomarker of Prognosis in <scp>IDH</scp> ‐Wildtype Glioma: Integrative Multi‐Omics and Spatial Analyses
TMEM106A independently predicts survival and correlates with myeloid-enriched transcriptional states in gliomas. Given its high expression in myeloid lineages in single-cell data, bulk upregulation is potentially driven by myeloid infiltration rather than tumor-cell intrinsic mechanisms. All findings are correlative; prospective studies are needed before any clinical use is considered.
Authors
- Dueng‐Yuan Hueng (ORCID: https://orcid.org/0000-0001-7868-3161)
- Yao‐Feng Li (ORCID: https://orcid.org/0000-0001-9601-8149)
- Wen-Shin Song
- Pei-Chi Chang
Institutions
- Cheng Hsin General Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/cam4.71454
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00