Dietary supplementation with sodium isobutyrate enhances growth performance and colonic barrier function in weaned piglets via microbiota-metabolite-host interactions
In conclusion, dietary supplementation with 1,000 mg/kg sodium isobutyrate was associated with improved intestinal morphology, reduced serum permeability, increased expression of tight junction proteins, and enhanced immune function in weaned piglets, suggesting enhanced colonic barrier function and providing dosage guidance and mechanistic insights for future applications.
Authors
- Xuan Qu (ORCID: https://orcid.org/0000-0003-1436-3315)
- Feng Gao (ORCID: https://orcid.org/0000-0003-3173-1650)
- Xiuyu Fang (ORCID: https://orcid.org/0009-0007-5862-814X)
- Baoming Shi (ORCID: https://orcid.org/0000-0001-8560-4564)
- Shuang Zhang (ORCID: https://orcid.org/0000-0002-8314-9286)
- Xuan Zhao (ORCID: https://orcid.org/0009-0002-2020-752X)
- Xuelin Wang (ORCID: https://orcid.org/0000-0001-5750-6035)
- Zhengyi Wang (ORCID: https://orcid.org/0000-0001-8609-480X)
- Zihan Chi
Institutions
- Southwest University (CN)
- Northeast Agricultural University (CN)
Publication Details
- Journal
- Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
- Published
- 2025-12-08
- DOI
- https://doi.org/10.1186/s40104-025-01310-w
- Citations
- 1
- Primary Topic
- Animal Nutrition and Physiology
- Type
- article
- Field-Weighted Citation Impact
- 1.19
Funders
- Southwest University
- Northeast Agricultural University