Risk prediction models for sarcopenia among community-dwelling older adults in China: a systematic review and meta-analysis

An increasing number of sarcopenia risk prediction models for older adults in Chinese communities have been developed, but the quality and applicability of these models in clinical practice and future research remain unclear. We conducted a systematic review to evaluate their performance. To systematically review published studies on risk prediction models for sarcopenia among community-dwelling older adults in China. We searched the China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), SinoMed, PubMed, Web of Science, Cochrane Library and Embase databases up to February 17, 2025, and extracted relevant information from the selected prediction models, including study design, data sources, outcome definitions, sample size, predictors, model development and performance. The risk of bias and applicability were assessed via the Prediction Model Risk of Bias Assessment Tool (PROBAST) checklist. Initially, we retrieved 2092 studies. After the screening process, 8 development models and 7 validation models were included from 9 studies. The prevalence of sarcopenia ranged from 8.3% to 30.6%, and the most commonly used predictors were BMI and age. All included studies had a high risk of bias, mainly due to inappropriate data sources and insufficient reporting in the analysis area. In the meta-analysis, we observed that the prevalence of sarcopenia was 20% (95% confidence interval: 0.14–0.26), the area under the curve (AUC) value of the development models was 0.89 (95% confidence interval: 0.84–0.95), and the AUC value of the validation models was 0.87 (95% confidence interval: 0.80–0.95). The overall accuracy of sarcopenia risk prediction models for older adults in Chinese communities is relatively good, but according to the PROBAST checklist, all studies have a high risk of bias. Future research should focus on developing new models with larger sample sizes, rigorous study designs, and multicenter external validation. The review protocol was registered in PROSPERO (registration ID: CRD420250653096).

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Publication Details

Journal
BMC Geriatrics
Published
2025-12-08
DOI
https://doi.org/10.1186/s12877-025-06816-6
Primary Topic
Nutrition and Health in Aging
Type
article
Field-Weighted Citation Impact
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article

Risk prediction models for sarcopenia among community-dwelling older adults in China: a systematic review and meta-analysis

Yan Sun, Xin Li, Yiwen Xu, Qinan Xian
BMC Geriatrics
Nutrition and Health in Aging
article

Risk prediction models for sarcopenia among community-dwelling older adults in China: a systematic review and meta-analysis

Yan Sun, Xin Li, Yiwen Xu, Qinan Xian
article en

Abstract

An increasing number of sarcopenia risk prediction models for older adults in Chinese communities have been developed, but the quality and applicability of these models in clinical practice and future research remain unclear. We conducted a systematic review to evaluate their performance. To systematically review published studies on risk prediction models for sarcopenia among community-dwelling older adults in China. We searched the China National Knowledge Infrastructure (CNKI), Wanfang Database, China Science and Technology Journal Database (VIP), SinoMed, PubMed, Web of Science, Cochrane Library and Embase databases up to February 17, 2025, and extracted relevant information from the selected prediction models, including study design, data sources, outcome definitions, sample size, predictors, model development and performance. The risk of bias and applicability were assessed via the Prediction Model Risk of Bias Assessment Tool (PROBAST) checklist. Initially, we retrieved 2092 studies. After the screening process, 8 development models and 7 validation models were included from 9 studies. The prevalence of sarcopenia ranged from 8.3% to 30.6%, and the most commonly used predictors were BMI and age. All included studies had a high risk of bias, mainly due to inappropriate data sources and insufficient reporting in the analysis area. In the meta-analysis, we observed that the prevalence of sarcopenia was 20% (95% confidence interval: 0.14–0.26), the area under the curve (AUC) value of the development models was 0.89 (95% confidence interval: 0.84–0.95), and the AUC value of the validation models was 0.87 (95% confidence interval: 0.80–0.95). The overall accuracy of sarcopenia risk prediction models for older adults in Chinese communities is relatively good, but according to the PROBAST checklist, all studies have a high risk of bias. Future research should focus on developing new models with larger sample sizes, rigorous study designs, and multicenter external validation. The review protocol was registered in PROSPERO (registration ID: CRD420250653096).

BMC GeriatricsVol. 26(1)
University of Electronic Science and Technology of China (CN), Chengdu University of Traditional Chinese Medicine (CN)
Openalex Percentile: Top 52%
Nutrition and Health in Aging
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